ciliary neurotrophic factor การใช้

• CLCF1 is closely related to other proteins called cardiotrophin-1 and ciliary neurotrophic factor.
• Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.
• It's a modified form of a naturally occurring protein known as CNTF ( ciliary neurotrophic factor ).
• Upregulation of FGF, TGFB, and ciliary neurotrophic factor ( CNTF ), is a classic marker for reactive gliosis.
• Ciliary neurotrophic factor ( CNTF ) effects embryonic motor neurons, dorsal root ganglion sensory neurons, and ciliary neuron hippocampal neurons.
• This gene encodes a member of the cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors.
• In June 1994, Regeneron halted clinical trials of ciliary neurotrophic factor for the disease because of the drug's severe side effects.
• Axokine acts on leptin-like pathways, but through a modified form of ciliary neurotrophic factor, another substance that occurs naturally in the body.
• Brain-derived neurotrophic factor and ciliary neurotrophic factor are both genetically engineered copies of neurotrophic factors, proteins that stimulate the growth of nerve cells.
• NT-501 is a product being developed by Neurotech that consists of encapsulated human cells genetically modified to secrete ciliary neurotrophic factor ( CNTF ).
• They did an experiment to attempt to repair ciliary neurotrophic factors, failed to promote neuronal survival and support of axonal growth at the spot of the injury.
• But it turned out that a genetically re-engineered version of the failed protein, known as ciliary neurotrophic factor, is very effective in helping people lose unwanted weight.
• A combination of NGF, glial cell-line derived neurotrophic factor ( GDNF ), and ciliary neurotrophic factor ( CNTF ) was presented to Dorsal root ganglion cultures " in vitro ".
• In certain CNS tissue, JAK / STAT signaling is also known to promote gliogenesis Significant levels of the ciliary neurotrophic factor ( CNTF ) are expressed immediately preceding gliogensis in response to environmental cues allowing the activation of the JAK-STAT signaling pathway.
• Bonni did his PhD and postdoctoral studies in the laboratory of Michael Greenberg between 1992 and 1999, where he discovered signaling mechanisms by which neurotrophic factors, including ciliary neurotrophic factor ( CNTF ) and neurotrophins, induce transcription and cell differentiation and survival in the nervous system.
• "' Ciliary neurotrophic factor ( CNTF ) "'typically has a high level of expression in Schwann cells associated with nerves that are healthy, but in response to nerve injury CNTF expression decreases in Schwann cells distal to the injury site and remains relatively low unless the injured axon begins to regrow.
• Other cytokines that signal through receptors containing gp130 are Interleukin 11 ( IL-11 ), Interleukin 27 ( IL-27 ), ciliary neurotrophic factor ( CNTF ), cardiotrophin-1 ( CT-1 ), cardiotrophin-like cytokine ( CLC ), leukemia inhibitory factor ( LIF ), oncostatin M ( OSM ), Kaposi's sarcoma-associated herpesvirus interleukin 6-like protein ( KSHV-IL6 ).
• Schwann cells play an important role in not only producing neurotrophic factors such as nerve growth factor ( NGF ) and ciliary neurotrophic factor ( CNTF ), which promote growth, of both the damaged nerve and supporting Schwann cells, but also producing neurite promoting factors, which guide the growing axon, both of which are discussed below.